Metabolism Alprazolam is extensively metabolized in human beings, largely by cytochrome P450 3A4 (CYP3A4), to 2 main Lively metabolites from the plasma: four-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of The 2 active metabolites are lower than 4% on the mother or father. The noted relative potencies in benzodiazepine